Effect of subnormal level of deuterium on glucose tolerance, serum HDL- and Na+-concentration

SOMLYAI G., MOLNÁR M., SOMLYAI  I., FÓRIZS I., CZUPPON  G., BALOG K., ABONYI  O., KREMPELS K.

     The paper presents the results of an open preclinical 90-day-long study to determine the effect of the deuterium-depleted water (DDW) on insulin sensitivity in volunteers.

     STUDY INCLUSION CRITERIA:

• men and women at the age of 25–60 years;
• impaired glucose metabolism with insulin resistance;
• patients with impaired fasting glucose (IFG): fasting blood glucose levels >5.6 mmol/l and < 7 mmol/l, or
• patients with impaired glucose tolerance (IGT): fasting blood glucose levels < 7 mmol/l and blood glucose levels 2 hours after a glucose loading, while performing an oral test for glucose tolerance ≥7.8 mmol/l and < 11.1 mmol/l;
• diabetes mellitus type 2 (DM2): fasting blood glucose levels > 7 mmol/l and/or blood glucose levels 2 hours after a glucose loading >11.1 mmol/l.

Based on the results of the oral tests for glucose tolerance (OTGT), 30 volunteers have been included in the study.

Active substance: deuterium depleted water (DDW)

• Dosage: 5 l/day, deuterium concentration in DDW: 110 ± 5 ppm. Route of administration: oral.

     The study showed that the use of DDW reduced the deuterium concentration in the blood plasma. Under the action of DDW, the elevated fasting glucose levels in volunteers decreased. The use of DDW significantly increased the levels of high-density lipoproteins (HDL) in the blood plasma and reduced the sodium concentration in the same. Under the effect of DDW, 11 volunteers showed a significantly decreased insulin resistance.